There’s new uncertainty about updated COVID-19 shots this fall after the Trump administration’s handling of a shot from Novavax. The company said Monday that U.S. health officials have asked for a clinical trial of its vaccine after it's approved. The unusual move comes after officials appointed by President Donald Trump delayed a decision on granting full approval to the vaccine. The shot has been available under emergency use since 2022 and is the nation’s only traditional protein-based option for COVID-19. Now experts are questioning whether other vaccines will be caught in the turmoil.

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Injection kits and doses of naloxone, a medication that reverses opioid overdoses, sit at the Cambie supervised consumption room in Bogota, Colombia, where people who use substances receive injection kits or bring their own drugs while learning safe practices, Sunday, April 27, 2025. (AP Photo/Fernando Vergara)

Luigi Mangione has pleaded not guilty to a federal murder charge in the killing of UnitedHealthcare CEO Brian Thompson, as prosecutors formally declared their intent to seek the death penalty against him. Mangione, 26, stood with his lawyers as he entered the plea Friday, leaning forward toward a microphone as he addressed U.S. District Judge Margaret Garnett. Asked how he wished to plead, Mangione said simply, “not guilty.” Mangione’s arraignment attracted several dozen people to the federal courthouse in Manhattan, including former Army intelligence analyst Chelsea Manning, who served about seven years in prison for stealing classified diplomatic cables.